I thought I'd drop one more link for some further reading on the topic of the last post. After reading it over I reckon you'll find a far less disjointed flow and approach to it all with all source materials and supporting evidence via linked studies and research to substantiate any sort of assertion being present. Overall the whole thing comes across as being quite impartial and very well informed with an incredible amount of depth to knowledge that's clear, relevant and always on topic. So far from what I can gather from overall general reading Aspirin can pretty much be ruled out as an effective means of protecting against the neurotoxic effects of prolonged and regular use of MDMA as a theoretical proposition. However actual testing with the intent of acquiring solid quantative data on it has yet to be done. Hit the link just below.


100% non-neurotoxic
 legal alternatives to MDMA and a slightly neuro toxic and currently legal alternative (Rave on...)

It seems the main concern about the use of MDMA is the levels of neurotoxicity that occurs with regular use despite plenty of evidence to suggest that its not an addictive substance. I also reckon that certain people might be able to develop conditioned psychological dependencies on it and eventually maybe go a bit loopy with increased paranoia whether warranted or unwarranted. Many so called legal highs have also tried to emulate MDMA's more desirable effects however they generally fall way short if the numerous accounts of various different kinds from people out there in actual use are to be believed. Excessively prolonged use of MDMA over time will very much so eventually leave your brain scrambled if taken exclusively or in combination with other recreational mood enhancing substances without some type of neurotoxicity reduction supplement. For regular users its mainly due to neuro receptor degradation over time with regular MDMA use as well as not giving your brain time to recover and restore it to equilibrium. This doesn't necessarily mean that it will have been restored to the previous levels before using MDMA as your brain might in fact just be manufacturing a lot more of the neuro transmitter to compensate for the lack of sensitivity to the original levels of naturally occurring neuro transmitter as a lot of the neural receptors in your brain will now be damaged. Meaning that hardened veterans that didn't take any supplementary protection to reduce the neurotoxic effects of MDMA originally "back in the day" are going to possibly need higher doses in order to feel any effect, it might be an idea to take the protective supplements this time round too if you intend on dropping again after all this time in order to preserve the neurotransmitters that are still fully functional.

There seems to be a lot of talk kicking around of MDAi which is legal and apparently does go some way to emulating certain elements of MDMA's desired effects but is said to lack the feeling of extreme euphoria and profoundness which I say/reckon is pretty much a key component to the experience of taking MDMA. Plus the "buzz" of MDAi apparently wears off relatively quickly meaning you'd probably have to redose at regular intervals in order to keep the high going. However the appeal is that there are apparently absolutely no neurotoxic affects at all in taking it. To give you some idea of what this means, alcohol has both neurotoxic and potentially addictive effects. However there are certain accounts that claim MDAi does little to encourage a party like mood leaving those same claimants saying that it left them feeling relatively sedate but incredibly alert and clear headed. To me it sounds suspiciously like something that could have more practical applications in being modified/adapted to be used by people with behavioral problems such as hyperactivity (attention deficit disorder) to help concentration when learning if it could be modified slightly to take the buzz and edge out of its effects. I guess the only way to know is to test it myself since the definition of "clear headed" will definitely be a subjective quantity or otherwise qualitative factor in this instance since the accounts I read came from users of other harder class A's with greater addictive and intoxicating properties. I think the real test would be see if advance tasks could be performed whilst under its influence or maybe it being able to enhance the ability to engage in some sort of academic learning, with actual processing, understanding and the retaining of it to greater effect.

Next up is 5 iAi which doesn't yet have a street name in being so new to have only mainly seen testing under lab conditions and apparently has only been tested on lab rats thus far until very recently if certain accounts are to be believed. For the moment it apparently remains legal. Its effects as observed in lab rats are claimed to be very similar to MDMA, however its potency isn't quite on a par with it. In terms of its neurotoxic effects (again in lab rats only) it has thus far been observed to have some slight neurotoxicity but from the said collected results could be seen as being negligible on paper. Note that I said on paper and the quantative results for this have been acquired via testing on Lab rats and not in humans

If I were to hazard an uneducated guess it might even prove to be less neurotoxic then alcohol in the appropriate dosage ratios however I wouldn't take that as sound advice in anyway shape or form until I can dig up comparative data for the neurotoxicity of both alcohol and 5 iAi in the same dosage.

First of all this raises a couple of questions, could they not come up with a none neurotoxic alternative to alcohol with the research done thus far with so called legal highs that are none neurotoxic? Sure they might make you more relaxed but then how would you go about emulating the blunting and slight buzz like effects of alcohol that increases with greater dosage since booze is not supposed to make you more alert and sharper by default. I guess at least it would get round the whole hangover thing.

Also if 5 iAi proves to be less neurotoxic then alcohol surely it would be safer to use then alcohol?

So how does 5 iAi actually stack up?

The results depend on who you believe. It ranges from absolutely spot on to kind of reserved. Although I wanted to believe the absolutely spot on account outright the most believable account I came across included many of the characteristic features of an MDMA experience but apparently nowhere near as intense including some of the more negative things that may occur with prolonged use of it beyond the so called "honeymoon period". As for the rest of the described experience they were very similar to the tail end of my back to back run one summer many moons ago hammering MDMA week in week out before knocking it on the head for quite a long period of time in getting to the point where I was consciously feeling it was actually messing my head up for all to get a little messy instead of being the pleasurable experience it was originally and should have been. That's is the highs weren't really being achieved any longer even with redosing unlike other highly addictive class A substances. I guess the abnormal increased levels in heart rate, increased blood pressure and sweating could be put down to the fact that it contains a particular type of amphetamine. However the mention of anxiety suggests to me that there might be increased levels of adrenaline being released too which I just learned is part of the process as enzymes in your brain break stuff down and convert things that would not normally occur under more normal circumstances.

Why not just work on making MDMA a speculated 90% less neurotoxic??!

I guess the whole point of this is harm reduction and testing of actual MDMA in animals and humans has proven that it is neurotoxic. However as mentioned earlier there are supplementary drugs that can apparently help to reduce the damage caused by MDMA's neurotoxic effects by a 90% margin if claims are to be believed. The petite concern being that specific types of neurotoxic reduction supplements also somehow slightly weakens the high that MDMA gives you when taken. Plus some of the supplementary courses looked a bit heavy with many things that had to be taken to achieve maximum damage reduction effect looking very much like the daily drug course of somebody unfortunate enough to have an incurable killer disease of some kind. Again as to how much the effect is diminished would be something I'd have to test for myself since again its obviously a highly subjective quantitative if not qualitative assertion when gauging it by each individuals "feeling" as it were, but I would have thought that it was worth it for the sake of reducing the potential neurotoxic damage by a massive 90% margin. Its just strange they hadn't thought to include/combine one of the more streamlined proven solutions within the actual pill itself in the appropriate/correct dosage in the first place as some of the solutions were apparently not expensive to produce or acquire. I hardly think people new to it would notice the difference since they wouldn't have had a supposed stronger experience of MDMA's effects to gauge it against anyway.

Other links: